Diamine Oxidase NEW CLEANER Formula – Must read if you have Mast Cell Activation Syndrome or Histamine Intolerance

Diamine Oxidase NEW CLEANER Formula – Must read if you have Mast Cell Activation Syndrome or Histamine Intolerance

Great news for those with Histamine Intolerance and Mast Cell Activation! The new, clean Diamine Oxidase formula is now available!
When I was in my 20’s, I was making all these fermented veggies and kombucha and kefir. Plus, I ate a lot of seafood and grass-fed beef.
My top veggies were spinach and mushrooms. And I loved pineapple and strawberries.

Sounds like a histamine nightmare – right? 

I just couldn’t figure out why my sleep kept getting worse and worse. I also was itching all the time. I even had constant post-nasal drip – YUCK! It was like a snot river in my throat. Seriously.
I had diarrhea several times a day. My acid reflux was off the charts. And I had terrible fatigue.
I could go on and on about all my histamine and mast cell symptoms. My health was a mess. And back then I just didn’t know what to do.
I didn’t know what Histamine Intolerance and Mast Cell Activation Syndrome were back then. But I knew I wanted to improve my health.
So, I started paring foods down further and further. Until I was mostly just eating chicken, lettuce, zucchini, squash, and herbs.
I ate so much zucchini. I’d be happy if I never saw a zucchini again! Lol! 
It got to where I couldn’t eat out. At all.
When I traveled, I had to pack a little electric burner and a pot. And then cook all my food, fresh in the hotel room.
You can imagine, this was hard as a young woman. I felt like I missed out on so much.
But when I learned about Diamine Oxidase, it was a Game Changer!!

What is DAO?

Diamine Oxidase (DAO) is the major histamine degrading enzyme in the gut.  You naturally make it in your body.
Low DAO is a major factor in Histamine Intolerance and Mast Cell Activation.
Low DAO has even been linked in research with Gluten Sensitivity, both mild and severe.
You can have low DAO because of certain genetic variants.  But genetics aren’t the only cause of low DAO.
Any form of gut inflammation or dysbiosis (where the gut bacteria is out of balance) can dramatically lower your DAO.
My DAO was very low because of my genetics. And made even worse by all the gut problems I had.
The DAO supplements allowed me to get more foods on board. Which was great!
So, why didn’t I recommend to my clients more? Why didn’t I write about it on my blog more?

A Lot of People Reacted to the Fillers in the Old DAO Formulas

Up until now, the DAO formulas had shellac and other “dirty” fillers. So, I had to use it very minimally.
I also found that many of my clients reacted to those fillers. And I had to be very careful who I recommended it too.
Unfortunately, most people with Mast Cell Activation Syndrome couldn’t tolerate that old formula.
Which was unfortunate, because DAO can make such a huge difference for people.
I was able to use it myself. But I do wonder if it caused some inflammation.
Here are the ingredients from the old formula:
Active Ingredients: Vitamin C (ascorbic acid), DAO
Active Ingredients: Microcrystalline cellulose, hydryxoypropylmethylcellulose, sucrose, rice starch, shellac, hydroxypropylcellulose, crospovidone, talc, carboxymethylcellulose and glycerol.
You can probably see why people reacted to those inactive ingredients.
So, I told a number of my sensitive clients with Mast Cell Activation Syndrome to wait for this new, clean formula.
Which finally happened!! We just got it in!

The New, Clean DAO formula is finally available!

I’m so excited about it! Here is the new formula.
Active ingredients:
Vitamin C (Ascorbyl Palmitate) 10 mg
Catalase 10mg
DAO 4.2mg
Ascorbyl palmitate is a form of Vitamin C. Catalase is a natural, human enzyme that activates DAO.
Inactive Ingredients:
Microcrystalline cellulose, silica.
Capsule Ingredients:
Clear vegetarian capsule, hypromellose, gellan gum.
The hyrpomellose and gellan gum are the capsule ingredients. People don’t normally have problems with those. But if you aren’t sure, you could open the capsule and put the contents in water.

>>>>>You can get the new DAO here (US and Canada):  https://mastcell360.com/shop/
This is much cleaner formula. I’m taking it myself now. And I’ve trialed it with a few clients who are seeing good results too.
So, keep reading to see if you should be taking DAO supplements.

How To Know If You Should Use DAO

Just the act of digesting creates histamine in the gut. This is true even if you eat the lowest histamine foods possible.
These are the people who should consider taking DAO:

  • Anyone with Mast Cell Activation
  • Anyone with Histamine Intolerance
  • Anyone with gut inflammation
  • Anyone with bowel issues
  • Anyone with gut infections
  • Anyone with mold toxicity
  • Anyone with genetic variants for DAO (ABP1/AOC1 genes)

If you are still eating higher histamine foods, DAO won’t be able to take care of all the excess histamine, though.
But, it can take the edge off.
After a few weeks of use, your gut histamine levels will be lower. And then you’ll likely find your food tolerance will increase!
I’m now switching my clients to this new formula. And talking with all clients about starting DAO.
DAO can likely help you, unless you are someone who can’t tolerate any supplements at all. 

How to Get the New, Clean DAO Formula + Free Shipping

The new, clean DAO is a clear capsule with white powder. If you see a formula with little round pellets inside the capsule, that is the old formula.
The new, clean formula just got released. And we have it in stock!
DAO comes in 60 caps or 120 caps. 

New to DAO? You should get the 60 capsule bottle if you haven’t tried DAO before. That way you can try it out.
If you have been taking DAO already, then you might want to get the 120 cap bottle.

>>>>>You can get the new DAO here (US and Canada):  https://mastcell360.com/shop/

How to Use DAO 

DAO works best when taken about 15 minutes before you start eating. That’s ideal.
But if you forget, just try to take it before you start eating.
I have both Mast Cell Activation Syndrome and Histamine Intolerance. And the DAO supplement has helped me eat a lot more foods. It has also helped my gut heal!
This is what I’ve learned works well:

  • For low histamine meals, I take 2 capsules before eating.
  • If my gut is really inflamed, I take 3-4 capsules before eating.
  • When eating at restaurants, I take 4 capsules before eating.
  • On special occasions if I’m having a high histamine food, I take 6-8 capsules.

If you have Mast Cell Activation or Histamine Intolerance. You’ll probably want to use this on a daily basis. And if you eat in restaurants, you’ll want to take DAO with you.
I don’t eat out a lot. But I do like to go out on occasion as a date with my hubby. I also like to be able to eat out sometimes with friends.
DAO has let me do that.
I’m also now able to eat a lot more foods than I ever could before.

I’m not eating high histamine foods every day. But in the past, I was reacting to all kinds of low histamine foods. This was because my gut was such a mess.
I think it will help you too. It’s definitely worth a try.

Who Shouldn’t Take DAO

DAO is naturally made in our bodies. So it is very safe to take.
But some people are in a state where they react to all supplements. This is usually due to significant Parasympathetic Nervous System and Vagal nerve dysregulation.
If you are reacting to all supplements, you want to work on your nervous system first. But if you can take supplements, you will likely do well with it.
This supplement has a very tiny amount of Vitamin C as Ascorbyl Palmitate. If you react to even tiny amounts Ascrobyl Palmitate, you shouldn’t take this supplement. You should wait for a different DAO formula I’ll be releasing in a few weeks.
Diamine oxidase is made from porcine kidney protein extract. If you have an IgE allergy to pork, you shouldn’t take DAO.

For the vast majority of people with Mast Cell Activation Syndrome or Histamine Intolerance, DAO is very helpful.

If you suffer with Mast Cell Activation Syndrome or Histamine Intolerance, DAO may be very helpful for you.
It can be especially helpful for:
GI Symptoms
Acid Reflux
Runny Nose
Allergy Type Symptoms
Breathing Trouble
Let me know if you try it!

>>>>>You can get the new DAO here (US and Canada):  https://mastcell360.com/shop/


  1. Sal

    Do you know a DAO enzyme supplement that is not made from pigs? I have a massive food sensitivity to pork?

  2. Melissa gonzales

    Is there any type of other nutritional deficiency that will alter Dao? Like the old you cant take this unless you take this too thick? I mean co factors. Just alittle bitter because the naturopath I trusted with more money than ive spent in my life shelled out so many supplements at me that it actually activated the mast cells. I believe that I stand with histamine intolerance maybe a sleeping lion inside me called mast cells. But she poked and poked at him and the last 2 years have been just awful. Obviously I stopped seeing her. And I still get very sad thinking about all the trust I lost. In healers and my own body. I was doing so well until the protomorphegens were fed to me. Im sure you know the brand im speaking of. She just kept saying all these other things that it was that didn’t make any sense. Im now more sensitive than ever before but have a small tolerance for some supplements. I think. I know that when i stop taking the few I do take i feel alittle worse. And I know that I have to tread lightly with supplements. But ive wanted to take Dao since forever. She didn’t like anything that wasn’t of this particular brand of supplements so it wasn’t even an option. Im taking the loritadine and the pepcid along with my anxiety meds each day. Im desperately looking for something to help the muscle pain and the constant reactions. But I have slowly been adding things and telling my mind to stop,stop,stop and distract. I just wasn’t sure if by trying a Dao I’d fall into the cofactor trap. I do know that its real however. In me for sure. Thanks for any advice 🙏

  3. Melissa gonzales

    I meant trick not thick. Lol first sentence and go old auto correct.

  4. Lien Nguyen

    Hi, I bought dao and tried it for the first time today. After lunch, I had cramps which subsided after about an hour. Do you think this is a normal reaction / the dao breaking down histamine? Or do you think it’s more of an allergic reaction and I need to find a different brand? Thank you!

    1. Suz, Mast Cell 360 Team

      Hi Lien,
      It’s hard to say without knowing your history. A couple things to consider: have they tried anything else new including a new food? It’s often helpful to keep a journal for food and supplements if you are not sure what may be causing reactions for you. Another thing to consider is how much of the DAO did you take? For the Mast Cell 360 clients, we usually say “start with a drop or sprinkle” and slowly build up if you are tolerating it. Again, we can’t say exactly what the best course for you might be so be sure to talk with your doctor or practitioner. If you do decide to try it again, go very slowly when introducing it.

      Suz, Mast Cell 360

  5. Jason Klinger

    i dont see this being any better. many people react to cellulose and ascorbyl palmitate

  6. Morten Krog

    Hi, does it breaks down the histamine release from eating oxalates and salicylates, digesting also?

    1. Suz, Mast Cell 360 Team

      Hi Morten,
      DAO helps reduce histamine in the gut, which will reduce it systemically because the histamine left in the gut gets dumped into the bloodstream.

      1. Ryan

        I see one on Amazon with vitamin c instead of B, is this the new formulation or is that the new formulation?

        1. Suz, Mast Cell 360 Team

          Hi Ryan, We just came out with the DAO with B with is Beth’s custom formula. Currently that formula is only available through Mast Cell 360 for clients, but we are hoping to have that open to the public in the very near future!

  7. Morten

    Is it effective to take if you are unlucky and I get a reaction to something you normally tolerate and then take a dao shortly after the onset of the reactions? Or hours later? It should, right?

    1. Suz, Mast Cell 360 Team

      Hi Morten,
      Everyone is different so we can’t say if and how this will work for you without knowing more about your case and health history. DAO is one of the top supplements Beth recommends. So if your reactions are related to histamine intolerance, this might help. Beth will often take it before meals. DAO works to reduce histamine in the gut which will reduce it systemically because the histamine left in the gut gets dumped into the bloodstream. If you are already experiencing reactions, you might want to consider some of the other supplements that have histamine lowering properties, like perilla seed extract. You can learn more about that here: https://mastcell360.com/why-perilla-seed-extract-is-the-mast-cell-supporting-supplement-youve-never-heard-about-for-those-with-mast-cell-activation-syndrome-histamine-intolerance/

  8. Morten


    I tried Histamine Block after the talks we have had here on this site, I reacted so bad.

    SO I changed the capsules with gellan gum out to hypromellose+water caps, now it works! Holy fuck. No reactions and doing much better!!

    So many can’t tolerate gellan gum, thats fermented!!!

    I’m now convinced that I probably can tolerate ancestral beef kidney also! Silica and gellan gum out of supps!!!

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