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Nervines and Adaptogens: Boosting Resiliency with MCAS 

Has your health been devastated by mold, too? 

If you’re like me, you don’t want to deal with mold again! 

So, you can imagine my reaction when I saw standing water in my basement. 

You probably know water damage can cause mold growth. 

I watched my anxiety start to surface. It was like watching a train coming toward me. 

But I knew if I panicked, I’d start flaring badly. 

And I wouldn’t be able to deal with the water.  

So, I took a deep breath.  

I remembered to be kind to myself. 

I reminded myself that I had support. 

And I told myself I had gotten through situations like this before, and I could do it again.  

Resiliency is one of the most important skills in life. Resiliency has allowed me to persevere through Mast Cell Activation Syndrome (MCAS), Mold Toxicity, and chronic pain. 

What comes to mind when you hear the word resilience? Perseverance? Mindset? 

That’s part of it.  

But there’s also a biological aspect to it. How your brain and nervous system work plays a big role in resilience. 

I’ve learned how to support my own resiliency better. In other words, I can bounce back quicker from stressful situations now. 

And I noticed how my resiliency has improved when I was dealing with this standing water. 

Keep reading to learn more about what resiliency is. And learn some of the top ways you can build your resiliency.  

You’ll learn more about: 


    • What is resiliency? 

    • Why is resiliency important in chronic illness? 

    • What can you do to build resiliency? 

    • My top nervous system resiliency supplements 

    • How nervines and adaptogens can calm mast cells  

Let’s jump right in! 


Resiliency and the Nervous System 

It’s important you know that this blog post is for informational and educational purposes. It’s not meant to treat any health condition or to be prescriptive for anyone.  If you have any medical condition, it is critical you work under the care and guidance of a licensed medical provider. 

The definition of resiliency is “the capacity to withstand or to recover quickly from difficulties; toughness.” 

But when we talk about resiliency in terms of our psychology and biology, there’s more to it. 

Resilience is the capacity to adaptively overcome stress and adversity while maintaining normal mind and body functioning. 

Resiliency doesn’t mean you don’t feel stress. It’s your ability to bounce back from a stress response. 

In other words, if your resilience isn’t strong, stress may result in: 


    • Experiencing pain or illness to a greater and longer degree 

    • Shifts in your psychology such as development of mental health conditions  

Someone who is highly resilient bounces back much quicker, with less likelihood of physical and mental adverse effects. 

Some people are naturally resilient. If you’d like to have more resiliency, it’s a skill you can continue to develop. 

Let’s look at what affects resiliency next. 


Why Some People Aren’t as Resilient as Others 

Research shows that resilience can be affected by different factors, like these: 


    • Epigenetic – genetic expression influenced by: 


        • Stress 

        • Diet 

        • Physical activity 

        • Other lifestyle choices such as tobacco and alcohol use 


    • Developmental – severe adverse events in childhood 

    • Psychological – cognition processes, personality traits, and coping mechanisms 

    • Neurochemical - chemicals in the brain  

These are a few factors that contribute to your level of resilience. 

Fortunately, you can improve your resilience! 


Resiliency Doesn’t Mean You Don’t Experience Stress 

I felt stressed out because my husband and I had already been through 5 rounds of mold remediation in our house. 

But I’ve been working on my resilience for a long time. 

So now, when I face stress like this, my health doesn’t plummet anymore. I don’t get stuck in a downward spiral of anxiety. And I don’t get the same kinds of stress-induced mast cell flares anymore either. 

I’ll tell you more about what you can do to build resilience in a bit. 

But first I want you to know why resiliency so important if you have chronic illness. 


Resiliency and Chronic Illness 

There was a time in my life when I was bedridden. I needed a cane just to walk down the hallway. 

I was in unbearable pain all the time. I could tolerate only a handful of foods. I was always anxious or depressed. Sometimes both. 

I had medical stress. I had daily life stress. I had trauma related stress. 

And I felt utterly hopeless for a time. 

My resiliency kept me going through this. But I needed to develop much stronger resiliency than what most people need for what I was dealing with. 

I know now that good resilience may encourage and accelerate healing. And it can provide a sense of well-being despite chronic illness.  

That’s one reason I’ve worked so hard at building my resilience. 

Resilience alone isn’t going to make all your problems go away. I’m definitely not suggesting that. 

Like me, you’ll still need to look at your root causes. These are underlying factors that are contributing to your illnesses, including Mast Cell Activation Syndrome and Histamine Intolerance. Mold Toxicity is a big one. 

But boosting your resilience may better equip you for healing as you tackle your root causes. 

Resilience experts believe that strengthening your resilience can help improve your health and ease illnesses in some instances. 

So, how do you build your resilience? 

That’s up next. 


Ways to Build Resiliency 

We’ll look at 2 different ways to build resiliency. 

First, you’ll read about increasing resiliency by supporting your nervous system. 

Then you’ll read about building resiliency with nervines and adaptogens. 

In both categories, I’ll share some new findings with you! 

I’ve added something new to my own protocol and I’m already noticing how it helps. 

Let’s start by looking at some free nervous system supports that you can get started with. And learn more about why they help build resiliency. 


Supporting the Nervous System 

Research has shown that stressful life events, trauma, and chronic adversity can greatly impact brain function and structure.  

And stress can keep your sympathetic nervous system engaged. That’s your fight or flight state.  

The human brain works in such a way that you don’t always enter recovery mode once a threat has passed.  

You may experience worry, stress, and anxiety well after an initial trigger.  

So, it’s possible to get stuck in the sympathetic state. And this isn’t where you want to spend the majority of your time.  

Did you know that this fight or flight state places big demands on your body? 

By calming your nervous system, you’re allowing yourself the best chance to bounce back, both mentally and physically. 

But you need to be in the parasympathetic state of rest, heal, and digest to do this.  

You can see why this is extra important if you have chronic illness. 

Working on your nervous system and engaging your parasympathetic nervous system is one way to build resiliency.  

Here are some examples of free modalities you can use to help strengthen your nervous system and build resilience. 



At its core, meditation is simply a practice that helps you improve your attention and awareness to help you calm your mind and body.  

Multiple studies have found that the brain structure of someone who regularly meditates often shows denser brain tissue as well as enlarged areas of the brain. (In a good way!) 

This seems to indicate that the neurons in those areas have more connections to each other. And the connections are stronger. Neurons are cells that signal all kinds of different jobs and responses in your body.  

And in these studies, the brain structure that shows denser brain tissue and enlargement are usually areas that control your: 


    • Senses 

    • Ability to think and concentrate  

    • Ability to process emotions 

That means people who meditate regularly have healthier brains. And they have a stronger ability to process emotions like fear, anger, and grief. In other words, they have greater resilience.  

Some people do much better with guided meditation than silent meditation. 

One of my favorite quotes by Thich Nhat Hanh, when asked about the best form of meditation, is his answer:

The best meditation is the one you do. 

And for some people, mind-body practices are even easier. Let’s look at a couple of examples of that next. 


Mind-Body Practices 

Mind-body practices like Qigong or yoga use gentle movement and mindful breathing to help you get into parasympathetic mode. 

Your parasympathetic state is the state of rest, heal, and digest. 

Qigong is a great way to get started with mind-body work. It’s free-flowing and uses gentle movements. It may be a better starting point than yoga for those who have EDS or hypermobility. 

Additionally, both Qigong and yoga have the benefit of being less intense forms of exercise.

This means they won’t increase your stress hormone levels, like cortisol. This is important if your cortisol levels are already out of balance due to stress! 

Again, it’s all about calming the nervous system. One of my favorite practices is Resonant Breathing.

TIP: If you have Mast Cell Activation Syndrome, you might want to skip hot yoga! Did you know that heat can be a mast cell trigger? 


Deep Sleep 

Sleep is critical for your body to heal.  

When you sleep, your normal body functions slow down.  All the energy you’d be expending while awake becomes available for repair.   

There is no substitute for restorative sleep.  

Psychologists report that sleeplessness can: 


    • Affect regulation of emotions 

    • Interfere with memory and learning 

    • Weaken the pain threshold 

    • Increase feelings of hopelessness or loneliness 

And they say that getting sufficient sleep is closely linked with positive mental health and resilience. 


Make Social Connections 

Numerous studies show social support is essential for maintaining physical and mental health.  

Remember how you read that resilience can be affected by genetics and your environment?  

Social support may moderate genetic and environmental vulnerabilities. 

A healthy support system is thought to bolster resilience to stress in several ways. 

Learn all about my tips for thriving at social gatherings with this post.  

A support system may decrease a person’s likelihood of engaging in risky or unhealthy behaviors. 

But a support system may influence different brain pathways as well! 

In human studies, those who didn’t have good social support showed heightened stress reactivity. This shows up as elevated heart rate, increased blood pressure, changes in heart reactivity, and elevated responses from the nervous system and endocrine system (hormone-related). 

So, don’t hesitate to reach out to your circle of friends and family. 

And if you are feeling like you are all alone, I invite you to check out the Hugs With Our Words Project. You can share your own experiences and read some words of encouragement. 

You’ve just read about some practices to build your resilience that you can get started with right away. 

But there’s another way you can build resilience, too. You can support yourself with nervines and adaptogens.  

Keep reading to learn more. 


Nervines and Adaptogens 

Nervines and adaptogens are both herbal in nature. And they both help to support your nervous system. 

I used both to help me build my resiliency. And I used both to help me through the stressful few weeks I had dealing with the water in my basement. 

So what are nervines and adaptogens? Let’s look at nervines first. 


What Are Nervines? 

Nervines are plants that have action on the nervous system. These are categorized as either stimulating or calming nervines. 

You are probably already familiar with some calming nervines like lavender, chamomile, and passionflower. 

Nervines support the central nervous system by reducing overactive stress responses. They help engage your parasympathetic nervous system. 

These herbs can help relieve: 


    • Muscle tension 

    • Ruminating thoughts 

    • Restless sleep  

    • Worry and anxiety

Some nervines also support the digestive system. 

That’s great news for those of us with Mast Cell Activation Syndrome. 

A huge percentage of your immune system and your nervous system is in your gut. And as you know, mast cells are a big part of your immune system’s response. 

So, healthy digestion and a healthy gut can go a long way to supporting your immune system and your mast cells. 

And calming the nervous system builds resiliency. 


What Are Adaptogens? 

Adaptogens are also herbs that help manage stress and stress responses.  

Herbs in this group have been shown to have modulating and balancing effects on multiple systems of the body – immune system, nervous system, and endocrine system. 

In other words, adaptogens level things out. 

For example, if cortisol is too high, adaptogens can bring it down. But if cortisol is too low, adaptogens can help bring it up to a healthy level.  

This goes for things like other stress chemicals, neurotransmitters, and hormones, too. 

And this can help build resiliency. 

People take adaptogens to help: 


    • Improve focus 

    • Boost mood 

    • Help immune function 

    • Alleviate anxiety 

    • Reduce fatigue 

    • Increase energy 

    • Cope with trauma 

    • Relieve stress 

To be considered an adaptogen, the herb must: 


    • Be safe, non-toxic, and non-habit-forming in normal doses 

    • Help the body cope with stress 

    • Assist the body in returning to balance by increasing or decreasing chemical reactions 

Combining adaptogens and nervines can be more effective than just one or the other in building resiliency, calming mast cells, and supporting the body. 

And some people prefer this natural way of healthcare when it comes to anxiety. Some prescription drugs for dealing with stress and anxiety have been shown to be addictive or have unpleasant side effects.  

I had such a complex case of MCAS. And I work with so many people with equally complex cases in the practice. So, I’m always looking for ways to support wellness. 

When it comes to resiliency, I’ve been using a product called BeSerene™. It combines adaptogens and nervines.  

It took my husband and I a few weeks to get the water in the basement resolved and everything remediated. During this time, I started using BeSerene™ to help me through the stress. 

And I’m loving it. 

Keep reading to learn more. 


Top Nervous System Resiliency Supplements: BeSerene™ Review 

I want to tell you about this product I’ve been using called BeSerene™. It comes in the form of a cream or oral supplement. 

Generally speaking, though, it’s been well-tolerated by people with MCAS and Histamine Intolerance. 

Both are combination products, though (they have multiple ingredients). So, I’ve also got a list of single ingredient supplements to consider, too. You might need to start with a single ingredient product if you are still highly sensitive. 

(If you have Salicylate Intolerance, keep reading for alternative options, too.) 

With any new supplement, be sure to talk with your healthcare provider who knows your full health history with any questions or concerns, including potential drug interactions. 

I can tell you that you shouldn’t use BeSerene™ if you are pregnant or breastfeeding. You also shouldn’t use it if you are taking prescription lithium. 

Further, the Healthy Gut Company that sells BeSerene™ reports that less than 1% of customers have reported excessive calmness, fatigue, diarrhea, and or a reduction in blood pressure while taking BeSerene™.  

If you like learning through video, be sure to check out this Facebook live with Steven Write from Healthy Gut.


BeSerene™ Cream 

Let’s start by looking at the BeSerene™ Instant Relief Cream.

Be Serene Cream

Topicals are sometimes better tolerated for those who are sensitive, so this may be where you need to start if you are ready for a combo product. 

BeSerene™ is made up of the following gentle but effective adaptogens and nervines. 


Mulungu is a tree that is native to Brazilian rainforests. The bark and roots are widely used for herbal medicinal purposes, including anxiety relief.

It’s one of the adaptogens you’ll find in both BeSerene™ products. 










In the brain, gamma aminobutyric acid (GABA) helps calm you when you are over-stimulated. It helps balance the feel-good chemicals like serotonin and dopamine. 

GABA is a nervine. 

GABA has been reported to help with: 


    • Relaxation 

    • Reduced pain perception 

    • Improved sleep 

    • Gut issues 



L-Theanine is an amino acid that has been shown to affect brain function by: 


    • Reducing stress 

    • Improving mood 

    • Helping with sleep 

    • Improving cognition and focus 

L-Theanine is a nervine. 

GABA and L-Theanine are well absorbed through the skin. That makes the BeSerene™ cream a good option for getting the benefits of both of these nervines. 


Albizia Supreme 

Albizia is a flowering tree native to parts of Asia.

Its flowers and bark have been used as a nervine to: 


    • Support mood 

    • Relieve stress and anxiety 

It also offers: 


    • Antimicrobial properties 

    • Antioxidant effects 

    • Anti-inflammatory effects 

    • Liver protective effects 

    • Lipid-lowering effects 


California Poppy 

This nervine is known for its calming properties and sleep support. 

The California poppy contains plant compounds which act on GABA receptors. GABA receptors respond to the neurotransmitter GABA, which is one of the main neurotransmitters responsible for sleep regulation. 

BeSerene™ has both California poppy and GABA which work independently, but together work even better to support the benefits each offers. 

Now, when people see “poppy” a frequently asked question is: Is it an opiate? 

California poppy does not contain opiates. It’s not related to the opium poppy at all and doesn’t contain any of the same compounds. 


How To Use BeSerene™ Instant Relief Cream 

When you are first starting with BeSerene™ Instant Relief (IR) Cream, you should start slowly. 

Start BeSerene™ Instant Relief Cream by only using ½ a pump of the cream. You’ll rub this into your temples or wrists at your pulse points.   

If you are highly sensitive, you may want to start with just a tiny drop. 

Do not try the products for the first time before driving or operating other equipment. 

Additionally, as you increase your dosage, you’ll want to take the same precautions. 

Remember, everyone is different. Your ideal dosage will not be the same as others. That’s why we always want you to start slow and increase gradually over time. 

You can work up to the suggested use, which is 1 to 2 pumps every few hours as needed. 

Because this can be used to promote good sleep, many people use this before bedtime. 

However, you can use it anytime, day or night. 

Many people report feeling the effects within 10 minutes! 

So, it may be helpful to use it preemptively if you know you’ll be facing a stressful situation.  

Or, because it works so quickly, you can use it as relief if you find yourself in an unexpected stressful situation. I used it frequently while we were trying to figure out where the water in my basement was coming from! It was really soothing.   

You can use BeSerene™ Instant Relief Cream on its own. Or you can get even more benefits by combining it with BeSerene™ Daily, the oral supplement. 


BeSerene™ Daily Oral Supplement 

Even though the two products have the same name, they don’t contain all the same ingredients. 

Both contain the adaptogen Mulungu.  

But other than that, the capsules have different adaptogens and nervines. That’s why using the cream and capsules together can provide even more benefits. 

Taken daily, the BeSerene™ Daily Oral Supplement can help to: 


    • Reduce anxiety and stress 

    • Improve sleep 

    • Increase health 

    • Increase energy and vitality 

BeSerene™ works by activating GABA receptors, stimulating parasympathetic neurotransmitters, and supporting parasympathetic tone. 

BeSerene™ Daily has the following adaptogens and nervines: 


Holy Basil (Tulsi) 

Holy basil (tulsi) is one of my favorite herbs. 

Tulsi is the star in my low histamine tea recipe!

It acts as a nervine, to help with psychological stress. 

Additionally, it has been shown to have these properties:


    • Antioxidant

    • Antimicrobial

    • Antihistamine

Related Article: The Best Antihistamine for Histamine Intolerance and Mast Cell Activation Syndrome

Alongside Mulungu, it promotes a deep sense of calm. 



Schisandra is a vine with red berries. It’s also sometimes called the five-flavor fruit. 

It’s a naturally occurring plant adaptogen with antioxidant properties.   

Data has shown that plant adaptogens, such as those occurring in schisandra may have benefits for: 


    • Chronic fatigue 

    • Cognitive impairment 

    • Immune protection 

    • Reduced levels of stress hormones

    • Liver protection 

    • Insomnia 



Shatavari is a member of the asparagus family. It’s an adaptogenic herb. 

It’s been used in Ayurvedic medicine for years. 

Like other adaptogens, shatavari may help with physical and mental stress. 

It’s also been shown to help in these ways: 


    • Anti-inflammatory properties 

    • Anti-depressant properties 

    • Boost the immune system 



Rehmannia is a flowering plant with adaptogenic properties. 

It has been shown to have the following properties: 


    • Antioxidant 

    • Anti-inflammatory  

    • Neuroprotective 

It’s been suggested that rehmannia can reduce your body’s stress reaction BEFORE stress, so when something goes wrong, you’ll be able to stay calmer. 

You can see that the BeSerene™ Daily supplement has a lot of great herbs that can support your brain and nervous system to help build resilience. And they offer a lot of other benefits that may help with mast cell reactions, too. 

Anything that has anti-inflammatory properties can help. Mast cells release histamine and other inflammatory mediators. 

So, if a product can help with your resilience and mast cell reactions, that’s a double win. 

And if you have Oxalate Intolerance, you’ll be happy to hear that I sponsored oxalate testing on this product, and it came back low oxalate at 2 capsules.  


How to Use BeSerene™ Daily 

Most people who use BeSerene™ Daily feel its effects in 45 minutes. 

However, our goal isn’t just immediate relief. Remember, we want to build resilience. For this, the best results occur when it’s used for 60 to 90 days in a row. 

If you are very sensitive, you should start slowly. You can open the capsule and start with just a sprinkle. You can slowly build up to 1 capsule per day, as tolerated. 

If needed, most people are able to work up to 2 capsules a day. 

And people who tolerate supplements can take up to 2 capsules every 3 hours during times of high stress. But most people don’t need that much. 

And remember, resiliency is about bouncing back from stress. 

You can use BeSerene™ to help rewire the nervous system and brain to be more resilient. 

Over time, it will downshift your body to a more natural, non-stressed-out baseline state.  

I like it so much that I keep at least a month’s supply on hand at all times. 

Check out BeSerene™ capsules here.

Be Serene Capsules

>>>Use this link to order BeSerene™!

And the great thing I love about all Healthy Gut products is they offer a 60-day money back guarantee. If it isn’t working for you, just contact their customer support for a refund. 

I love that you can try this product to see if it will work for you. 

Finally, let’s look at some single-ingredient options if you aren’t ready for a combo product yet. 


Nervous System Support Supplements 

If you are still very sensitive, you may need to start with just one ingredient at a time. 

You can always try the combo products once you are further stabilized with your health and able to handle more. 

You read some product information about some of these supplements earlier, so I’ll just touch on these lightly. 

They are all either nervines or adaptogens or in some cases both. That means you’ll get the same benefits you read about earlier with nervines and adaptogens. 


    • Rhodiola – nervine, adaptogen, mast cell stabilizing 

    • GABA – low salicylate, nervine 

    • Liposomal Zen (can be used topically) – low salicylate, contains both GABA and L-theanine, nervine

When you start with any of these, start with just one at a time. If you start with several, it defeats the purpose of starting with single ingredients. You won’t know what you are reacting to if you do have a reaction. 

And just like we talked about with BeSerene™, you’ll want to start any of these single ingredient supplements low and slow, too. 

In the Mast Cell 360 practice, we say “drops or sprinkles.” You can put just a little bit into your water to start. Slowly build up from there as tolerated. 

And as always, be sure to talk with your healthcare provider who knows your full history and risk factors before starting anything new. 

Resiliency is so important for recovering your health. 

I’ve made it a priority in my own life and seen noticeable differences in how I recover from stressful situations now. 

Whether you choose to support yourself with some of the nervous system practices you learned about or some of the nervines and adaptogens, I hope you’ll get more resilient every day! 

Wishing you well! 

Be Serene Capsules

>>> Check out BeSerene™! 

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