Nervous System Balance is Essential in Mast Cell Activation Syndrome and Histamine Intolerance

Nervous System Balance is Essential in Mast Cell Activation Syndrome and Histamine Intolerance

A big part of my healing with Mast Cell Activation Syndrome and Histamine Intolerance was from working on my nervous system.

When I say a big part, I mean it was at least 50% of my healing.

I was really sick with both Mast Cell Activation Syndrome and Histamine Intolerance. And I didn’t have a lot of bandwidth for stress. This is one of the big reasons I knew I had nervous system dysregulation.

One day when I was still very sick, I had a dentist appointment. Just a routine cleaning. Then I had to stop at the grocery. And I hit traffic on the way home.

When I got home, I had to unload the groceries. And I felt so wiped out. Not only that, I felt fried. Like I couldn’t think anymore.

I just crashed. For most people, that many activities in one day wouldn’t be a big deal. But for me, it was too much.

After this, my husband came home and wanted to go out to dinner. I remember I just started crying. Even thinking of going out again was just too much.

At this time, I could hardly take supplements. I had to open the capsules and take just a little sprinkle out. I did this with all my supplements.

I just opened them up into water and made this micro-dosing drink every day. That’s all I could tolerate. Before this time period, though, I couldn’t tolerate any supplements at all.

Other clues to me that I had a nervous system imbalance were:

  • Startling easily
  • Weak gag reflex
  • Trouble relaxing
  • Difficulty sleeping
  • Trouble handling change
  • Feeling wired after too much conversation

I started taking yoga when I was 19. And went on to become a yoga therapist and a seasoned meditator. I also did a lot of counseling and personal growth work.

I loved these things. And they helped. But I was still having trouble relaxing and calming down from stress. Even with all that practice and experience under my belt.

I was already doing so much:

  • Yoga and meditation
  • Supplements
  • Clean foods
  • Reverse Osmosis water
  • Air purifiers.

But I was still bed-ridden most days! Until I implemented these targeted Nervous System Balancing practices. Then, everything started coming together.

That’s when my health really turned around.

There are ways to calm down your nervous system. Some work much faster than others.

But there is one major misunderstanding I hear a lot about Nervous System Balancing. It is that Nervous System Balancing programs will cure any health issue.

This simply isn’t true for Mast Cell Activation Syndrome and Histamine Intolerance.

When people are told this, they end up really frustrated. Because they work hard to do a program 100%. But they still aren’t better.

But another big mistake is when people only work on foods, supplements, and their environment. If they skip the Nervous System Balancing, they stay stuck.

I tell my clients that there are 4 major pieces to healing in Mast Cell Activation Syndrome and Histamine Intolerance.

  1. Identifying and Addressing the Root Triggers. You have to find out what is causing your symptoms and work on addressing all the root triggers.
  2. Foods and Supplements. Targeting the right, healthy foods for your body. And adding the right supplements at the right time in the right order.
  3. Making sure your environment is free of mold, EMFs, and other toxins. Basically, having good air, good water, and low EMFs.
  4. Nervous System Balancing. Supporting the Parasympathetic Nervous System balance – this is the rest, heal, digest, and restore system.

All 4 of these parts are essential to your healing when you have Mast Cell Activation Syndrome or Histamine Intolerance.

If you only do 2 or 3 out of the 4 steps above, it really doesn’t work if you have been chronically ill for a while.

I’ve seen this over and over with all the people I’ve worked with who have Mast Cell Activation Syndrome or Histamine Intolerance.

For me Nervous System balance was 50% of my healing process. For some people, it might be 33%. But regardless, we have to do it when we have Mast Cell Activation Syndrome and Histamine Intolerance.

PNS balance is one of the essential first steps in my MCAS protocols. Especially if you have:

  • Reactions to foods
  • Reactions to supplements
  • Mold toxicity
  • Lyme
  • Epstein-barre
  • Other chronic infections
  • Long term illness of any kind
  • Major stressors
  • Medical traumas

If you have any of these factors, nervous system balance is a great place to start!

So, let’s look at how you can tell if you have a dysregulated nervous system.

Signs that your Nervous System is Dysregulated in Mast Cell Activation Syndrome and Histamine Intolerance

If you have 1 or more of these symptoms, you’ll want to work on your nervous system balance:

  • Startling easily
  • Weak gag reflex
  • Trouble relaxing
  • Difficulty sleeping
  • Fatigue
  • Trouble handling change
  • Feeling wired after too much activity
  • Any type of immune disorder

Also, these events in the last 7 years increase your need to work on your nervous system balance:

  • Divorce
  • New significant relationship
  • New additions to your family
  • Death of a loved one
  • Witnessing violence
  • Surgery
  • Overworking
  • Moving
  • Retirement
  • Financial concerns
  • Toxic relationships
  • Losing a job
  • Starting a new job
  • New relationship
  • Feeling isolated
  • Worries about political changes
  • Worries about safety

Further, if you had any childhood or even adult trauma, it is really essential to work on your Nervous System Balance. This kind of trauma includes:

  • Experiencing or witnessing sexual, physical, emotional, or mental abuse
  • Childhood neglect
  • Sudden loss of a loved one
  • Witnessing a traumatic event
  • Bullying, harassment, or abuse at school or work
  • Military Trauma
  • Having a family member with a serious illness or injury
  • Significant childhood medical issues (like surgeries)

As you can see, if you have Mast Cell Activation Syndrome or Histamine Intolerance – you’ll most likely need to work on your Nervous System Balance.

So, I’m going to teach you what I’ve learned that let me get my life back. And this is what I use with my clients too.

Before we talk more about how to get your nervous system back in balance, we need to look at the branches of the nervous system.

Then, I’ll tell you about ways you can get your nervous system back in balance.

What to know about the Nervous System and Mast Cell Activation Syndrome

The nervous system, immune system, hormone system, and stress levels are all majorly connected.

In fact, you can’t accurately look at the immune system without looking at hormones, the nervous system and stress.

This is an established field of medical study. It is called psychoneuroendicrinoimmunology. Or psychoneuroimmunology for short.

I know. The word psychoneuroimmunology isn’t a short word.

But what it means is simple. That your state of mind significantly changes your immune system, nervous system, and hormone system.  

And also, this means problems in your immune system can cause problems in your nervous system, hormones, and mind state.

One of the ways that your nervous, immune, and hormone systems are linked is through a nerve called the Vagal Nerve. 

PNS balance is one of the essential first steps in my MCAS protocols. Especially if you have:

  • Reactions to foods
  • Reactions to supplements
  • Mold toxicity
  • Lyme
  • Epstein barre
  • Other chronic infections
  • Long term illness of any kind
  • Major stressors
  • Medical traumas

This is exactly why many people with chronic illness get depressed. Because their immune system and nervous system get out of whack.

I knew this was extremely important. Which is why I did my Masters’ research in this area: Psychoneuroimmunology in Mast Cell Activation Syndrome.

Basically, that research was about how your mind, immune system, nervous system, and hormones are all linked. And how to get them back in balance.

Here is how this all affects Mast Cells.

Mast Cells are in many of your body’s organs and tissues. This includes very high numbers the brain.

Your brain is a part of your nervous system. And your brain is the driver of many of your body’s functions.

There are 2 branches of the nervous that really affect Mast Cell Activation Syndrome and Histamine Intolerance. These are the Parasympathetic Nervous System (PNS) and the Sympathetic Nervous System (SNS).

The Sympathetic Nervous System is the part of your brain that reacts to threat or danger. Think about how you feel when someone cuts you off in traffic. Or when you take a fall. That jolt is the Sympathetic Nervous System kicking in.

When your Nervous System perceives any kind of danger, it causes the “fight, flight, freeze” reaction.

This means that it prepares your body to:

  • fight the danger
  • flee (run away) from the danger
  • or freeze in place.

Let’s look at what each of these means. Fight means that your body is revving up to physically fight the danger.

Flee is when you want to escape or run away from the danger.

But freezing is what happens when you can’t fight or run. Think of it as rolling over and playing dead.

Animals sometimes do this when they fear an attack by another animal. Humans sometimes do this, too.

One of the problems with the fight/flight/freeze reaction is that it comes from a part of your brain that can’t think. It can only react.

So it will react the same way to a minor stressor, like driving in traffic, that it would if a tiger were ready to attack you.

Fight/flight/freeze causes your brain to release chemicals called stress hormones. These chemicals cause your muscles to tense, your heartbeat to increase, and your breathing to change.

One of the stress hormones is cortisol, which is involved in your body’s immune system actions and reactions.

You may already know that low cortisol can make Mast Cell Activation Syndrome and Histamine Intolerance worse.

But high cortisol can be a big issue too.

Since Mast Cells are part of the immune system, they are triggered into action by the cortisol. The Mast Cells start to release inflammatory chemicals in your brain and throughout your body. The inflammatory Mast Cell chemicals then cause the release of more stress hormones. And this produces more cortisol, which activates your Mast Cells again.

This activating and re-activating of your Mast Cells continues in a feedback loop.

When you have Mast Cell Activation Syndrome and Histamine Intolerance, the loop causes even more inflammation in your tissues and organs. And this triggers your symptoms.

Unfortunately, we live in a Sympathetic Nervous System Dominant state. This is part of living in modern culture. Traffic, bills, news reports, health worries, conflicts – you are surrounded by stressors all the time.

So, what can you do to stop this feedback loop that fires up your Mast Cell Activation and Histamine Intolerance Symptoms?

The most important way is to work on your Nervous System Balance

Parasympathetic Nervous System Importance in Mast Cell Activation Syndrome and Histamine Intolerance

How do you stop the feedback loop that fires up your Mast Cell Activation and Histamine Intolerance Symptoms?

Here is where the Parasympathetic Nervous System gets involved.

First, it’s important to understand that your mind and your body are intricately connected.

You learned about this in the beginning of this post. Scientists refer to the connection between your mind and your nervous, hormone, and immune systems as psychoneuroimmunology. This system examines these mind-body connections.

One of the things scientists know is that if your mind is experiencing distress or anxiety for any reason, your body responds immediately to the stress.

And one of the major ways your body responds is to activate your Sympathetic Nervous System and your Mast Cells.

Your Mast Cells have 100’s of roles in your body. Did you know your Mast Cells also play a part in regulating emotions?

This whole process can become a problem for people with Mast Cell Activation Syndrome and Histamine Intolerance. Especially when the stressful situations that are creating stress and anxiety in your mind and body don’t stop.

Do you have a job that is stressful? Or something in your home life that is stressful? If you have stress all the time, it is called chronic stress.

Trauma can also create a state of chronic stress. You’ll learn more about this further down.

Chronic stress keeps pounding your mind with the feeling of distress and anxiety. And this keeps activating your Mast Cells. Then they keep producing inflammation and histamine release. They also affect your emotions. And this then causes you even more feelings of distress and anxiety.

Can you see how stress can keep your Mast Cell Activation Syndrome or Histamine Intolerance flared up?

To stop the feedback loop that is activating your Sympathetic Nervous System and the Mast Cells, you have to get your Parasympathetic Nervous System involved.

The Parasympathetic Nervous System is what interrupts the Fight/Flight/Freeze reaction that has been triggering your Mast Cells.

Remember how your Sympathetic Nervous System is the Fight/Flight/Freeze response?

Well, your Parasympathetic is the Rest, Heal, Digest, and Restore response.

The Parasympathetic does this by reducing your heart rate, blood pressure, and muscle tension. It also slows down your breathing.

Once all these things are slowed down or decreased, your brain stops flooding the body with stress hormones, and the Mast Cells stop firing.

My first symptoms when I’m in a flare is swelling, redness, and pain in my fingers. I’ve done experiments where I start thinking stressful thoughts to see what happens in my fingers.

Like thinking – I’m never going to get my gut better. I’m never going to get foods back on board. I should have never gone to India in the first place. That’s where my gut issues started. Etc. If I let my thoughts spin like this, within 2 minutes my fingers will start swelling, hurting and turning red. This is from mast cell activation.

But – get this. When I shift into my Parasympathetic Nervous System, my fingers start to calm back down within 5 minutes!

It’s that powerful.

For people with Mast Cell Activation Syndrome and Histamine Intolerance, it is vital to be able to get the Parasympathetic Nervous System going. This is so that the Mast Cell activation can slow down or stop.

There are many actions you can take to relax the mind and the body.

Let’s take a look at those now!

Ways to Balance the Parasympathetic Nervous System

One simple first step is to pay attention to your breathing. Make sure you are not holding your breath. Some people tend to hold their breath when they feel stressed.

It helps if you slow down your breathing, too. Try breathing in to a count of 4, then breathing out to a count of 4. Slowed breathing helps to engage the PNS, so that you can feel calmer.  

Another method is Box Breathing or Tactical Breathing. This is where you breathe in for a count of 4. Then pause your breath for a count of 4. Then exhale for a count of 4. Then pause the breath for a count of 4. You can repeat that multiple times.

Sometimes it’s hard to remember to slow down your breathing. And some people have trouble taking deep breaths.

But also…I haven’t seen these breathing methods alone fix the Parasympathetic Nervous System for people. I tried for years myself to use yoga and breathing, but I lost a lot of time.

So, you’ll probably need some other tools.

If you are ready to get serious about your Mast Cell Activation Syndrome or Histamine Intolerance, you’ll need a program that teaches a number of tools. One I recommend most frequently in my practice is the Gupta Program.

You can get the first 3 videos free. Do keep in mind, thought – this program is really in depth and goes into much more than what you see in the free intro.

And the great news! They offered a discount for Mast Cell 360 followers. You can get $50 off the Gupta Program Online + 3 Month Webinar Series package with coupon code Mastcell360.

—>Click here to check out the Gupta Program for PNS Balance

Use Code MastCell360 for $50 off

The Gupta Program was developed by Ashok Gupta, after he suffered for many years with Chronic Fatigue Syndrome. His system is based upon years of research and practice.

He developed tools based upon his research and he used them on himself. And his Chronic Fatigue Syndrome symptoms decreased significantly.

Not only that, he learned that those tools worked with other conditions that are involved in Mast Cell Activation Syndrome and Histamine Intolerance.

The Gupta Program Includes:

  • 15 Brand New Interactive Video Sessions online with all the latest healing content, shot in the stunning mountains of Switzerland
  • Numerous Audio Exercises and Meditations, all available online
  • 12 Weeks of Coaching Webinars directly with Ashok, and you can ask questions
  • An accompanying Manual and Floor Chart
  • Direct access to the healing private Facebook group
  • Regular newsletters updating with new information
  • A full one year Money Back Guarantee

What the Gupta Program Can Do

The Gupta Program can teach you several tools to “train your brain” so that the Parasympathetic Nervous System comes into balance.

It has been shown to be helpful with many conditions, including:

  • Chronic Fatigue Syndrome
  • Fibromyalgia
  • Irritable Bowel Syndrome
  • Chronic Pain Syndrome
  • Multiple Chemical Sensitivities
  • Anxiety and Stress
  • Other inflammatory Conditions, like Mast Cell Activation and Histamine Intolerance

What the Gupta Program Can’t Do

Just remember, these types of programs won’t fix all biochemical, genetic, or structural problems in MCAS/HIT. The Gupta program needs to be done alongside food, supplement, and environment supports.

And in order for the program to help with your symptoms, you have to put the tools into action.

I’ve gotten feedback from my clients on numerous different systems for PNS balance. This includes DNRS. The vast majority of my clients have preferred the Gupta Program.

This is because:

  • it is more soothing
  • it is more manageable, time wise
  • people are more likely to stick with it
  • it comes with the coaching webinars where people can ask questions and get guidance

Here is the link to the Gupta Program for you, if you want to check it out.

—>Click here to check out the Gupta Program for PNS Balance

Use Code MastCell360 for $50 off

Feedback on the Gupta Program from Mast Cell 360 clients

“I started the Gupta Program 4 weeks ago and I’m already noticing I’m reacting less to foods. I’m also sleeping better and feel much calmer! I’m so excited about the changes!” -Angela R.

“I’ve been doing the Gupta Program and I’m noticing that my brain fog is lifting. I can exercise more. And I can sleep better. I was even able to start some new supplements that I reacted to before.”

-Janey C.

“I felt on edge all the time and couldn’t meditate or do breathing practices before. I just couldn’t settle down. But since starting the Gupta program, I feel so much calmer! I have finally felt centered enough to breathe and meditate. I love doing it before bedtime because I fall asleep faster. Oh, and my pain has been getting better too!”

-Francis S.

“I have a family member who is very stressful to talk to. I was getting flared up every time I got off the phone. I also felt agitate and it was hard to make decisions afterward. After doing the Gupta program, I feel like I can make better decisions in my life. Like when to set better boundaries and get off the phone. This is translating to my health issues – my sleep, digestion, and reactions are all starting to get better too!”

-Danielle G.

“I’ve been sick for a long time with fatigue, bad brain fog, lots of inflammation, and intolerance to a lot of foods. I tried so many things – supplements, diets, detox programs. Nothing was working. Then I tried the Gupta program. Within a few weeks, I noticed my fatigue improving. Then my brain started feeling clearer. A few weeks later, my inflammation started decreasing. Now I’m finding I can eat more foods and my supplements seem to be doing what they are supposed to do now.” -Dan R

—>Click here to check out the Gupta Program for PNS Balance

Use Code MastCell360 for $50 off

Special Considerations in Trauma in Mast Cell Activation Syndrome and Histamine Intolerance

As we said above, if you have had childhood or adult trauma, balancing your Parasymathetic Nervous System is particularly important. Some types of trauma include:

  • Experiencing or witnessing sexual, physical, emotional, or mental abuse
  • Childhood neglect
  • Sudden loss of a loved one
  • Witnessing a traumatic event
  • Bullying, harassment, or abuse at school or work
  • Military Trauma
  • Having a family member with a serious illness or injury

If you have had any of these traumas, you need to work even hard to balance your PNS.

This is why I say PNS support is 33% to 50% of the healing process. For those who experienced early traumas like this, the PNS support is a full 50% of healing.

Trauma causes changes to happen on the biochemical and structural levels of the body that can stick around a long time. It also makes the fight/flight/freeze reaction overly reactive.

Talk therapy can be helpful to understand what happened. But it won’t balance the nervous system. So, counseling won’t fix the nervous system dysregulation piece.

And telling the story of the trauma repeatedly can be re-traumatizing.

This is why programs like the Gupta Program can be so helpful.

Parasympathetic Nervous System Balance is an essential part of healing your Mast Cell Activation Syndrome and Histamine Intolerance symptoms.

If you are serious about bringing your PNS into balance and healing your Mast Cell Activation Syndrome and Histamine Intolerance symptoms, you can start now.

The Gupta Program is one of the best ways to help you balance your PNS.

You deserve to feel better. Why not get started today? It is risk free with a one year Money Back Guarantee.

—>Click here to check out the Gupta Program for PNS Balance Risk Free. Or use Code MastCell360 for $50 off

If you try it, I’d love to hear from you on what you noticed. Just post a comment below! 

Download Free Mast Cell 360 Guide for MCAS button

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References on Parasympathetic Nervous System Balance for Mast Cell Activation Syndrome and Histamine Intolerance

Afrin, L. B. (2013). Presentation, Diagnosis, and Management of Mast Cell Activation Syndrome. In D. B. Murray, Mast Cells: Phenotypic Features, Biological Functions and Role in Immunity (pp. 155-232). Hauppauge, New York: Nova Science Publishers.

Afrin, L. B. (2014). The presentation, diagnosis and treatment of mast cell activation syndrome. Current Allergy & Clinical Immunology, 146-160.

Afrin, L. B. (2016). Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity. Bethesda: Sisters Media.

Beaven, M. A. (2009). Our perception of the mast cell from Paul Ehrlich to now. European Journal of Immunology, 11–25 .

Broadbent, et. al. (2012). A brief relaxation intervention reduces stress and improves surgical wound healing response: A randomized trial. Brain, Behavior, and Immunity, 212-217.

Brown, R. P., & Gerbarg, P. L. (2012). The Healing Power of the Breath: Simple Techniques to Reduce Stress and Anxiety, Enhance Concentration, and Balance Your Emotions. Boston: Shambhala.

Căruntu, C., Boda, D., Musat, S., Căruntu, A., & Mandache, E. (2014). Stress-Induced Mast Cell Activation in Glabrous and Hairy Skin. Mediators of Inflammation, 1-9.

Chikahisa, et. al. (2017). Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance. Nature, 1-11.

Crivellato, E., Beltrami, C., Mallardi, F., & Ribatti, D. (2003). Paul Ehrlich’s doctoral thesis: a milestone in the study of mast cells. British Journal of Haematology, 1921.

Daruna, J. H. (2013). Introduction to Psychoneuroimmunology. Oxford: Academic Press.

Forsythe, P. (2015). The Parasympathetic Nervous System as a Regulator of Mast Cell Function . In M. R. Hughes, & K. M. McNagny, Mast Cells: Methods andProtocols (pp. 141-177). New York: Springer.

Frieling, et. al. (2011). Evidence for Mast Cell Activation in Patients with Therapy Resistant Irritable Bowel Syndrome. Gastroenterol , 191-194.

Gerbarg, et. al. (2015). The Effect of Breathing, Movement, and Meditation on Psychological and Physical Symptoms and Inflammatory Biomarkers in Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 2886-2896.

Mourya, M., Mahajan, A. S., Singh, N. P., & Jain, A. K. (2009). Effect of Slow- and Fast Breathing Exercises on Autonomic Functions in Patients with Essential Hypertension. Journal of Alternative and Complementary Medicine, 711–717.

Nautiyal, K. M., Ribeiro, A. C., Pfaff, D. W., & Silver, R. (2008). Brain mast cells link the immune system to anxiety-like behavior. Proceedings of the National Academy of Sciences, 18053-18057.

Porges, S. W. (2011). The polyvagal theory: Neurophysiological foundations of emotions, attachment, communication, and self-regulation. New York: W.W. Norton.

Theoharides, T. C. (2002). Mast Cells and Stress—A Psychoneuroimmunological Perspective. Journal of Clinical Psychopharmacology, 103-108.

Vanuytsel, et. al. (2013). Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast-cell dependent mechanism. Gut, 1-7.

Vicario, et. al. (2010). Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress. Brain, Behavior, and Immunity, 1166-1175.

Wynne, O., & Sarkar, D. K. (2013). Stress and Neuroendocrine–Immune Interaction: A Therapeutic Role for β-endorphin. In A. W. Kusnecov, & H. Anisman, The Wiley

Blackwell Handbook of Psychoneuroimmunology (pp. 198-211). West Sussex: Wiley-Blackwell.

Yeo, K.-T. J., Babic, N., Hannoush, Z. C., & Weiss, R. E. (2017, May 17). Endocrine Testing Protocols: Hypothalamic Pituitary Adrenal Axis. Endotext, pp. 1-28. Retrieved May 12, 2018, from Endotext.”

Yuan, et. al. (2010). Role of mast cell activation in inducing microglial cells to release neurotrophin. Journal of Neuroscience Research, 1348-1354.


  1. Candy

    I have mold toxicity and I am so too I from air and enviroment chemical sensivity and electrical metal taste mast cell and yeast in musty house and bad air town ..I’m not stong enough to watch anything on line and I keep getting something like shingles and bad scary brain jerking all over rashes and tiny weird scab zits and I’m flamed hives and tissue on top of head sore mmu eyes and nose never stop burning and metal taste stays and yeast..all smells bother me have mthfr gene and mold toxicity

    1. Beth O'Hara

      I’m so sorry to hear this, Candy. I hope you can get out of the mold soon. That will help. Then you’ll need to find someone you can see in person who can help you with a very gentle, mast cell friendly mold detox protocol.

  2. Karen Queen

    I cried all the way through as I read this blog and you described very much of my “stuff” I will need to come back to this Gupta program once I finish up a couple of others that address structure and energy med. With time and money triggers as well as all of the above, I am already addressing overwhelm) It sounds like this program may be a good fit when time is right. The info you have provided is quite invaluable for me, and I will begin with essential oils which I have, and have been gathering waiting for right info to seriously get into. Thank you so much for providing that and so much more. Also a few days ago you asked what I eat for breakfast, and I have struggled with because of a food addiction that I know I need help with, and again I cry because so far, I haven’t been able to face giving it up. Also, you gave recipes for breakfasts that I said sounded so good and that I wanted to try; and then I promptly lost them, so will have to locate so I can do that, so can answer you question. This feeling of needing to answer your question haunts me – my guess is a part of a negative feed back loop and guilt program that may be running me. (big clue!) Thanks again, Beth. I appreciate you so very much and all that you have endured to get here.

    1. Beth O'Hara

      Hi Karen, Thank you for sharing your story. Please be gentle with yourself. Thought patterns can be changed and I want you to know that you aren’t alone and that there is hope. Again, be kind and gentle with yourself. You deserve that peace of mind. I think it sounds like the Gupta program may be a big help to you. It has certainly been beneficial for me. Here’s a quick link to the recipe page on the blog. If you ever lose track, you can always go to the website, then blog, then choose recipes from the drop down menu. Best regards, Beth

  3. Katie

    Thank you so much for sharing so much information! There’s so much here that resonates with me I’m seriously hoping this is the missing link in my puzzle and battle with MCAS. I’m from the UK and barely any Dr’s even know what it is so I was treated with arrogance and ignorance for more that 20 years. Including a year in therapy where I was actively trying to heal my apparent psychological illness after a rhemy told me I was unstable and hurting myself which was causing all these awful symptoms – I was 26 and on a walking stick at the time. How I wished it was my brain making me so ill. I’m 30 now and finally one private Dr told me of this mystery illness and believes it to be underlying my systematic symptoms but testing is illusive and extremely expensive. The NHS has yet to recognise let alone test for or treat it with only a few specialists understanding its intricacies. I’m not well enough to work anymore so need to get my body on board so I rejoin the land of the living! I spent the last 3 years in a house with mould problems and my health just deteriorated horribly. I’ve now moved so am hopeful I can begin rebuilding. Ive only been able to get so far with diet – I started reacting to salicylates and have soaring oxalate levels from an organic acid test, gluten, dairy, soy and corn are a hard no – but gut infections (methane dominant sibo and dysbiosis) recurrent utis and mould toxins are a part of my picture that I’m trying to heal. I’m also under investigation for a metabolic disease. My biggest problem is getting meds and supplements on board. I can’t take anything – I end up spiralling rapidly into an intense adrenal fatigue with psychosis, hallucinations and terrifying peaks and/or shingles. I’ve had well over 150 outbreaks in the last 8 years. An immunologist told me it was nothing to do with food in 2016 so I lost a few years there for sure. I have a particularly violent reaction to corn – – it gives me huge personality and psychological mood shifts, actually making me suicidal and violent against myself for a few hours which completely wipes me out. Until a month ago I was down to 3 foods, and then down to just 1. I was terrified and just had enough. This wasn’t living, I was barely existing. I had been in India doing more yoga teacher training and got stuck in lockdown, the stress of getting back home was huge and combined with living off boiled Cabbage and sugar water for 2 months I think caused a major relapse in symptoms. I’m pleased to say with a few months of rest and being brave with foods I’m now eating nearly 15 foods! This is the biggest variety I’ve had in over a year. I’m just really hoping that by working on my CNS and micro dosing I might be able to get my body to accept the supplements that could help me heal my issues. I can’t afford to work with a practisioner right now, I have no or very little income as I’m rarely well enough to move all that much. This source is invaluable to me and I’m really optimistic about healing. I can’t face the 2 weeks of antibiotics, that will more than half kill me so just hearing that you also couldn’t tolerate supplements until digging deeper and healing the nerves first has given me hope that I can do the same. That maybe there is a way out of all this. That I’m not the only one with this story and I’m not the anonomly that countless Dr’s and specialists have told me I am.

    1. Beth O'Hara

      Thank you for sharing your story. I’m so sorry to hear you have been through so much. You are definitely not alone and not the only one with this story! I am glad to hear you are able to increase your foods and that the blog has been of help. That was one of my main reasons for creating it, to help people get more information and hopefully be able to start their healing. You may want to also consider supporting your nervous system from numerous angles. Here are a few other steps you can look into that might be tremendously helpful: This book, Accessing the Power of the Vagal Nerve:,aps,156&sr=8-1&linkCode=sl1&tag=bethohara09-20&linkId=8dca4471673b3a274d256b65f3b691d0&language=en_US
      and this form of PNS support: BrainTap:
      Best wishes!

  4. Nancy Enman

    Thank you Beth for this very valuable info… fingers swell up and get red too! I have very low cortisol levels, so have been supplementing with 5 mg Hydrocortisone… I know the Hydrocortisone if likely causing more MC’s to be released. I feel nauseous after I take it. But I have been told it could be dangerous for me to go off of it. About 2 years ago, I started losing weight unintentionally–20 lbs in about a year. Also lots of nausea and some vomiting. I had a Lyme diagnosis in 2013, also have Fibro, Hashimoto’s and T1 Diabetes. Now looks like MCAS is on the horizon too. I have been taking Cromolyn and Ketotifen, and over the course of the last year or so, I have gained back 15 lbs of the 20 that was lost. It seems I am having a positive reaction to those meds. I have done some alternative therapies (PEMF in particular last year) Initially, it seemed to be working and I felt better….but the therapist would always tell me, ‘your body is always in sympathetic mode’. I have just started working with an Immunologist/Allergist and will be discussing some blood work I had done recently–and of course the blood work shows my Tryptase levels are within the normal range. I cannot afford an alternative practitioner as I live on disability benefits that aren’t even adequate to cover living expenses, so anything extra is out of the question. I use quercitin and nettle tea to help with some of the management. Waiting to speak with Immunologist to see if he will offer more meds. Just looking for some guidance on where to go from here? Thanks again, you’re a very valuable asset to all of us, we need more like you who have this understanding of such complex medical issues.

    1. Suz, Mast Cell 360 Team

      Hi Nancy,
      Beth is so glad the resources are helpful for you! With what you’ve described, if she were in your shoes, she would prioritize nervous system supports and looking into mold toxicity. Have you seen those posts yet?

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