Oxalates Part II: Addressing when you have Mast Cell Activation Syndrome and Histamine Intolerance
I knew I had Mast Cell Activation Syndrome and Histamine Intolerance. But I hadn’t figured out the Oxalate piece yet.
My husband and I were going on vacation. It was at the end of December. That was the time of year when my excruciating joint pain always flared up.
During these flares, I would have to use a cane to walk. And even then, I was struggling to walk to the bathroom.
We’d planned on some beach time, which I was desperately craving. But the muscle and joint pain meant it took me 2 full days just to get packed.
Then… I had to use a wheelchair at the airport. There was no way I could walk through the terminal. It was the first time I had to use a wheelchair.
I tried to look on the bright side. I mean, hey – you get through security so much faster! But it was hard to take so many people staring at me with pity. Or worse: looking at me with bewilderment because I “didn’t look sick.”
I was just 31 at the time.
I hadn’t figured out this strange pattern of cycles. My joints would get much better from April to October. I could walk just fine then. But when fall hit, I always became so much worse.
The pain was like having ground glass rubbed into my joints. It was excruciating!
In my late 20s/early 30s, I had to wear orthopedic style shoes because of the pain. That’s hard to swallow for a young woman. After all, those shoes aren’t exactly stylish!
I saw so many doctors. I was told I had a rare form of rheumatoid arthritis. But the heavy medications didn’t help at all. They just made me feel worse.
Then I was told it must be related to sunlight changes. That I needed melatonin. And to use a sunlamp in the winter. Well, that didn’t change anything.
I was even told several times by doctors that I must want to be sick. They thought I was attached to being ill for some reason. Looking back, this was so dismissive and disrespectful.
This was definitely the most challenging time of my life – not just physically, but emotionally, mentally, and spiritually. Even socially – I lost many of my friends during this time period.
Have you had this happen, too?
Well I didn’t give up. No matter how hard it got. No matter how often I wanted to give up.
Finally, I learned about oxalates! And the pattern finally made sense!
I wasn’t crazy!
Here’s what I finally figured out…
When I went gluten-free, I replaced wheat with even higher oxalate grains and nuts. Like almond flour, quinoa, and millet.
And I was eating very high oxalate foods much, much more often in the wintertime.
As I worked on lowering my oxalate foods (and taking some targeted supplements), my joints and muscles stopped hurting.
My pain levels dropped from a 7-9 every day to a very manageable 4-6 on my pain scale.
It was like getting a new lease on life! And I even got to trade in my orthopedic shoes for a few pairs of cute shoes!
But I made 1 major mistake. I didn’t know how to lower oxalates slowly.
Lowering oxalates too fast can cause oxalate dumping. So, I want you to know how to avoid that!
No matter what, do NOT go on a low oxalate diet cold turkey! Oxalate dumping is miserable and awful.
I’m going to show you how to lower oxalates in a safer way.
But first, let’s review what oxalates are.
What you need to know about oxalates if you have Mast Cell Activation Syndrome or Histamine Intolerance
Oxalates are naturally occurring microscopic crystals. They’re high in certain plants. Which means they often show up when we’re trying to eat healthy. These plants can include different types of:
You’ll learn about which ones specifically are high in oxalates down below.
Unfortunately, oxalates act as a so-called “anti-nutrient,” which means they can do more harm than good.
These anti-nutrients are basically poisons made by plants to keep animals (and humans) from eating them. They are also a type of natural antibacterial or antiviral for plants.
While that’s all great for the plants, it’s bad news for us.
In our bodies, the sharp oxalate crystals can cause inflammation and pain. Especially when they build up to high levels.
Most people know about oxalates because of their role in kidney stones. However, oxalates can show up in other conditions as well.
Just a few of these include:
- joint pain
- muscle pain
- brain issues
- food intolerances
You can check out more background information about oxalates in this post:
Have you checked your oxalate levels yet? If not, you can do that with this test:
So, if you know you have oxalate issues – what should you do? Let’s cover that next.
Steps to look into if you have Oxalate Issues with Mast Cell Activation Syndrome or Histamine Intolerance
- If you are eating high oxalate foods, step these down very slowly. Do NOT go low oxalate cold turkey. This can cause oxalate dumping and can make you feel really bad.
See the next section on oxalate foods.
- Consider B6, if low. Check your B6 levels. If you have low B6, this is a very clean option: Start slowly with sprinkles and gradually increase.
- Consider oxalate binders. Oxalate binders are supplements that are used to attach to oxalate molecules. When oxalates are bound, they are not absorbed. Instead, they are removed from the body through the urine and stool. Take with meals. Start very low and slow.
Now, most oxalate sites will tell you to use citrates. That’s fine if you don’t have Mast Cell Activation Syndrome or Histamine Intolerance.
But if you do have Mast Cell Activation Syndrome or Histamine Intolerance, citrates won’t work so well for you. This is because citrates are from fermentation. So they are naturally high in histamine.
Here are safe options for those with Mast Cell Activation Syndrome and Histamine Intolerance:
- Magnesium Malate
Oxalate binders can be really helpful, but they aren’t the only thing to think about. Let’s look at high oxalate foods next.
Foods High in Oxalates to be aware of if you have Mast Cell Activation Syndrome or Histamine Intolerance
Wondering which foods are high in oxalates?
I was surprised when I first learned how many “healthy” foods were high in oxalates. Things like root vegetables, nuts, and greens.
If you have high levels of oxalates, these are the top foods to avoid.
Highest Oxalate Foods in the Western Diet:
- Swiss chard
- Sweet potatoes
That list is a great place to start. When you’ve spent some time off those foods, you can tweak your diet further.
But again, if you have high oxalates, DON’T reduce these high oxalate foods too fast. This could make you really sick. You want to reduce those high oxalate foods slowly.
If you go too fast, you could start experiencing oxalate dumping. Let’s talk more about that next…
How to Avoid Oxalate Dumping and Reduce Oxalate Foods Slowly if you have Mast Cell Activation Syndrome or Histamine Intolerance
If you find out you have high oxalate levels, DO NOT GO LOW OXALATE COLD TURKEY!
This is very important! Why?
Because switching to only low oxalate foods all at once can make you very ill. You may cause “oxalate dumping.” Believe me, you don’t want to start dumping oxalates in large amounts.
What is oxalate dumping?
Oxalate dumping is the fast release of oxalates into your bloodstream. Basically, your body sees this as its chance to detox and it starts eliminating oxalates as fast as it can.
Oxalate dumping can increase the symptoms you already have. Plus, it can spark new ones, due to the sudden detox.
But it’s not good to get rid of the stored oxalates all at once. It’s like opening the floodgates… and all you have is a few narrow winding streams. You know what’s going to happen: They are going to overflow.
Your body is not going to be prepared to handle all these oxalates just yet. It will see this spike in oxalates in the bloodstream as poison. To respond to the poison, it will set off your immune system. This can show up as inflammation and sometimes debilitating pain.
You will need a step-by-step plan to s-l-o-w-l-y start reducing oxalates in your body.
Start out by simply eliminating the list of 6 Highest Oxalate Foods in the Western Diet mentioned earlier.
If you’ve been using a lot of almond flour, almond butter, and almond milk, don’t go cold turkey on almonds. Start reducing your dependence on these products and using alternatives listed above instead.
Instead of almond flour, try white rice flour, cassava flour, and/or flax meal.
Instead of almond butter, try coconut butter (coconut manna).
Instead of almond milk, try coconut milk or flax milk.
There really are great alternatives to most high oxalate foods. It may take a bit of time to restock your pantry, but it will all be worth it in the end. Feeling good is a great reward.
Again, just make sure you go very slowly. Reduce oxalate foods just a little at a time.
My good friend and oxalate expert Monique Attinger, taught me that you can alternate high and low oxalate days to go even slower.
Monday – higher oxalate day
Tuesday – slightly lower oxalate day
Wednesday – higher oxalate day
And continuing like this to step things down.
However you do it, be sure to listen to your body. And if you start feeling worse, back up and get guidance from an oxalate expert.
If you have a history of kidney stones, definitely get help from an oxalate expert before stepping foods down.
Foods low in Oxalates and Histamines
As you’ll see, there are many foods that are low in oxalates AND low in histamines, too!
Here are foods to focus on:
Low Oxalate/Low Histamine Foods List
- White rice
- Cassava flour (Otto’s only! – use in moderation)
- Flax meal
- Hi-Maize resistant starch
- Miracle Noodles, Miracle Rice
- Sweet Potato Starch and Sweet Potato Starch Noodles (the starch is low oxalate, the flour is high oxalate)
- Turnips, greens or root
- Bok choy
- Brussels sprouts
- Butter lettuce
- Butternut squash
- Chinese cabbage
- Daikon radishes
- Dandelion greens
- Green and red cabbage
- Kale- Lacinato or Dinosaur, not Curly
- Leafy greens
- Mustard greens
- Napa cabbage
- Onions-any kind
- Parsley-flat only
- Peppers, bell or hot
- Red and green leaf lettuce
- Apricot – fresh
- Cranberry – fresh
- Lemon – 1/2 tsp (not always tolerated in elimination)
- Lime – 1/2 tsp (not always tolerated in elimination
- Pear – Bartlett or Bosc only
- Raspberries – ¼ cup (not always tolerated in elimination)
- Fruit dishes made with allowed ingredients
- Bison (not ground)
- Eggs – plain, cooked, pasture-raised ONLY if you tolerate them (do Egg Zoomer test to find out) AND not during elimination
- Salmon (frozen), must have been gutted and frozen within 30 minutes of catch
Nuts and seeds
- Coconut meat, fresh
- Coconut milk – 100% coconut milk only, no additives
- Pumpkin seeds
Fats and Oils
- Cold pressed avocado oil
- Cold pressed flax oil
- Grass fed butter
- Ghee from grass fed cows
- Extra virgin coconut oil
- Extra virgin olive oil
- Extra virgin palm oil (unprocessed)
- MCT oil
- Homemade salad dressings with allowed ingredients
- Fresh meat drippings
Spices and Herbs
- Curcumin powder (can replace turmeric if oxalates are a concern)
- Salt – only unrefined such as Real Salt, Celtic Sea Salt, Himalayan Sea Salt
- Monk fruit – only 100% monk fruit, no fillers
The above sweeteners do not raise blood sugar levels.
Remember, anything that raises blood sugar levels increases histamines!
Homemade sweets with allowed ingredients are okay.
- Baking powder
- Baking soda
- Cream of tartar
- Homemade relishes with allowed ingredients
- Cocoa butter (white chocolate with no additives)
- Remember to freeze leftovers right after cooking
You can find great low histamine, low oxalate recipes here.
Bottom Line and What to Do
If you’re overwhelmed and wondering where to start, here’s a checklist:
- Check Oxalate Levels by using this test: >>> Great Plains Organic Acid Test with Oxalate Markers>>>CANADA Great Plains Organic Acid Test
- If oxalates come back high, try adding B6 and safe oxalate binders (Start very slowly)
- Slowly lower oxalates from foods (Start by eliminating the top 6 listed earlier)
- If you need more guidance, seek out oxalate experts. There is a great FB group called Trying Low Oxalates you can use.
- Be sure to read the MastCell360 guide on the Common Root Causes behind Mast Cell Activation Syndrome:
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References on Oxalate Issues for those with Mast Cell Activation Syndrome or Histamine Intolerance
Brzica H, Breljak D, Burckhardt BC, Burckhardt G, Sabolic I. Oxalate: from the environment to kidney stones. Arh Hig Rada Toksikol. 2013;64:609 30.
Chaplin AJ. Some observations on the demonstration of calcium oxalate in tissue sections. Stain Technol. 1974;49:165-73.
Chetyrkin SV, Kim D, Belmont JM, Scheinman JI, Hudson BG, Voziyan PA. Pyridoxamine lowers kidney crystals in experimental hyperoxaluria : a potential therapy for primary hyperoxaluria. Kidney Int. (2005) Jan;67(1):53 60.
Givler E. Lecture on Oxalates. Environmental Toxins and Genomics Conference. 2019.
Holmes RP, Ambrosius WT, Assimos DG. Dietary oxalate loads and renal oxalate handling. J Urol. 2005;174:943 7. discussion 947.
Owens S. Low Oxalate website. http://lowoxalate.info/
Siener R, Schade N, Nicolay C, von Unruh GE, Hesse A. The efficacy of dietary intervention on urinary risk factors for stone formation in recurrent calcium oxalate stone patients. J Urol. 2005;173:1601 5.
Ykelenstam Y. Low Oxalate Low Histamine Diet – The Missing Link?